Management of different triggering factors effects in sensitive skin with a specific dermo-cosmetic product

Polena Helena, Fontbonne Arnaud, Abric Elise, Giraud Félix, Chavagnac Marlène, Graizeau Christelle, Ardiet Nathalie, Trompezinski Sandra, Sayag Michèle

NAOS Group, Aix-en-Provence, France

NAOS ILS, Aix-en-Provence, France

Related topics

Sensitivity / Rosacea

Sensitive skin syndrome (SSS) is characterized by barrier function alteration and inflammation in response to several stimuli (mechanical, chemical, thermal, pollution…) but no consensus exists on how to assess SSS.

To confirm its efficacy, the product was evaluated on skin barrier function, immediate and long-lasting soothing effect after stripping or chemical irritation (temperature, microcirculation, capsaicin test), and on Asiatic and Caucasian subjects. In a slit face study, 30 females with SSS applied the product on one half-face for 28 days twice daily. At day 0 (D0) and D28, heat-cold stress was performed on both half-faces (radiofrequency system and dry air by 3 cycles 45±5°C,15±5°C). Before and after stress, IL-1α and S100A8/9 release, hydration and global score of unpleasant sensations were measured.

After 28 days of product application, the product significantly improved skin barrier and presented a soothing effect whatever the triggering factor. In addition, up to 91% of Asiatic and Caucasian sensitive skin subjects judged the product efficient and the burden of sensitive skin significantly improved (BoSS score -14.1%). The product significantly reduced IL-1α after heat-cold stress at D0 (32.6%, p<0.001), and at D28 (27.7%, p<0.01) vs control. At D0 and D28, the S100A8/9 release with heat-cold stress was prevented by the product. Moreover, the product significantly improved hydration (up to +45%), and the global score (down to -50%) before and after heat-cold stress vs control.

Polena Helena, Fontbonne Arnaud, Abric Elise, Giraud Félix, Chavagnac Marlène, Graizeau Christelle, Ardiet Nathalie, Trompezinski Sandra, Sayag Michèle

NAOS Group, Aix-en-Provence, France

NAOS ILS, Aix-en-Provence, France

Oral presentation: Sensibio Defensive DOCUMENT

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Management of different triggering factors effects in sensitive skin with a specific dermo-cosmetic product

Introduction

Objectives

Materials and Method

Results

Conclusions

PDF: WCD 2023

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