Positive contribution of active molecules combined with sun filters evaluated by in vivo biomarkers analysis

Compared to non-irradiated placebo condition, UV irradiation induced squalene oxidation by 2-fold, a decrease of catalase activity by 1.5-fold and a photo-isomerization of UCA by 5-fold. Compared to the irradiated placebo, combination of ectoine and mannitol with sun filters provided a better protection of squalene oxidation (76.8%; p<0.01), catalase activity (84.4%; p<0.001) and UCA isomerization (53.9%; p<0.01). Compared to filters alone, the active complex added to filters provided significant additional protection of squalene by 26% (p<0.05), catalase activity by 31% (p<0.05) and trans-UCA synergistically by 24% (p<0.01).

This non-invasive in vivo study performed on specific biomarkers demonstrates the interest of combining UV filters with a biological protection to prevent UV damages induced by sun exposure such as induction of oxidation, decrease of endogenous antioxidant defence systems and induction of photo-immunosuppression.

Photoprotection, immunosuppression, antioxidant.

Fontbonne A.^1,2, Abric E.¹, Moga A.³, Callejon S.^1,2, Giraud F.^1,2, Garin C.¹, Ardiet N.¹, Cadars B.^1,2, Graizeau C.^1,2 and Trompezinski S.^1,2

¹NAOS Group, Aix-en-Provence, France

²NAOS ILS, Aix-en-Provence, France

³QIMA Synelvia, Labège, France

Arnaud Fontbonne^1,2; Elise Abric²; Alain Moga³; Sylvie Callejon^1,2; Félix Giraud^1,2; Cécile Garin²; Nathalie Ardiet²; Benoît Cadars^1,2; Aurélie Guyoux²; Sandra Trompezinski^1,2

¹NAOS Institute of Life Science, Aix-en-Provence, France

²NAOS Group, Research & Development Department, Aix-en-Provence, France

³QIMA Synelvia, Labège, France

Fontbonne, Arnaud^1,2; Teme, Baba^1,2; Abric, Elise²; Lecerf, Guillaume³; Callejon, Sylvie^1,2; Moga, Alain³; Cadars, Benoît^1,2; Giraud, Félix^1,2; Chavagnac-Bonneville, Marlène^1,2; Ardiet, Nathalie²; Guyoux, Aurélie²; Trompezinski, Sandra^1,2

¹NAOS InstituteofLife Science, Aix-en-Provence, France

²NAOS Group, Research& Development Department, Aix-en-Provence, France

³QIMA Synelvia, Labège, Franc