To date, more than 10 countries worldwide have published guidelines and recommendations for the prevention and treatment of hand skin lesions caused by frequent hand hygiene. Overall, HCW should avoid harsh washing with overly hot water, and prioritise the use of hypoallergenic foam cleansers or syndets with a pH of 5.5, which do not contain fragrances or antibacterial agents. After washing, hands should be gently dried. The use of gloves should preferably be limited to specific tasks, and after taken off, hands should be washed and dried gently. Specific dermocosmetics are internationally recommended to restore or prevent alteration of the skin barrier due to frequent hand washing, the use of ABHS, and wearing of protective gloves. Fragrance-free, water-rich emollients or moisturizers with a pH of 5.5 should be used preferentially as often as possible